stem cells

Stem Cells for Cell Therapy in Orthopedics

Are umbilical cord mesenchymal stem cells advantageous over bone marrow mesenchymal stem cells for cell therapy in orthopedics? Mesenchymal Stem cells (MSC) from umbilical cords (UC) are of increasing interest for cell therapy in degenerative musculoskeletal disorders as they present little ethical consideration and are reported to contain immune privileged cells, which may be suitable for allogeneic based therapies. The …

spinal disc stem cell therapy

Mesenchymal Stem Cell Therapy for Intervertebral Disc Degeneration

The potential role of mesenchymal stem cell therapy for intervertebral disc degeneration: a critical overview. Low-back pain is the most common health problem for men and women between 20 and 50 years of age, resulting in 13 million doctor visits in the US annually, with significant costs to society in terms of lost time from work and direct and indirect …

osteoarthritis graphic

Cartilage Regeneration in Osteoarthritic Patients

Cartilage Regeneration in Osteoarthritic Patients by a Composite of Allogeneic Umbilical Cord Blood‐Derived Mesenchymal Stem Cells and Hyaluronate Hydrogel Results from a Clinical Trial for Safety and Proof‐of‐Concept with 7 Years of Extended Follow‐Up Few methods are available to regenerate articular cartilage defects in patients with osteoarthritis. We aimed to assess the safety and efficacy of articular cartilage regeneration by …

stem cell treatment for knee injury

Mesenchymal stem cells in the treatment of traumatic articular cartilage defects

A Comprehensive Review Articular cartilage has a limited capacity to repair following injury. Early intervention is required to prevent progression of focal traumatic chondral and osteochondral defects to advanced cartilage degeneration and osteoarthritis. Novel cell-based tissue engineering techniques have been proposed with the goal of resurfacing defects with bioengineered tissue that recapitulates the properties of hyaline cartilage and integrates into …

knee cartilage injury

Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells

Knee Cartilage Regeneration with Umbilical Cord Mesenchymal Stem Cells Embedded in Collagen Scaffold Using Dry Arthroscopy Technique Articular cartilage injuries lead to progressive degeneration of the joint with subsequent progression to osteoarthritis, which currently becomes a serious health and economic issue. Due to limited capability for self-regeneration, cartilage repair remains a challenge for the present-day orthopedics. Currently, available therapeutic methods …

anatomy of the knee

Stem cell application for osteoarthritis in the knee joint: A minireview

Knee osteoarthritis is a chronic, indolent disease that will affect an ever increasing number of patients, especially the elderly and the obese. It is characterized by degeneration of the cartilage substance inside the knee which leads to pain, stiffness and tenderness. By some estimations in 2030, only in the United States, this medical condition will burden 67 million people. While …

patient receiving PRP injection

Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. …

Clinical Trial Using Stem Cells for Rotator Cuff Tears Approved by FDA

Two clinical trials run by Sanford Health have been approved by the U.S. Food and Drug Administration to use fat stem cells from the abdomen to heal rotator cuff tears. The trials are small so far, but researchers hope to expand them to bigger trials in the future. The team performed an hourlong procedure to remove fat from the abdomen, …

Could Stem Cell Treatment for Back Pain Help With the Opioid Epidemic?

Back pain affects over 28 million people in the United States alone. Drugs like oxycodone, hydrocodone and methadone are often prescribed for patients suffering from back pain, even though they are some of the most addictive prescribed drugs on the market. According to research, there has been a 400 percent increase in overdoses due to prescribed opioid drugs since 1999. …