BPC-157

Pentadecapeptide BPC-157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has between demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. In addition, BPC 157 seems to protect organs of the body and decrease pain in damaged areas. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues. BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, Crohn’s disease, and prevent stomach ulcers. Those who suffer from discomfort due to muscle sprains, tears and damage may also benefit from treatment with this peptide.

CJC 1295

CJC 1295 stimulates growth hormone secretion and will keep a steady increase of HGH and IGF1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.

GHK-CU Collagen and Aesthetic Peptide

GHK-Cu is a naturally occurring copper complex that was first identified in human plasma, but has hence been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, antioxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. First, it seems to act as a potent protector of tissue and anti-inflammatory agent that controls the oxidative damage that occurs post-tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction.

Ipamorelin

Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. ¬e potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin and aldosterone. It is for this reason Ipamorelin has been considered the rst selective GH Secretagogue.

IRGD Cancer Targeting Peptide

IRGD is a cyclic peptide that binds to integrins that are expressed on tumor endothelial cells. Upon binding, a protease cleavage event is activated. When this event is activated the peptide is then able to bind neuropilin-1, activating an endocytotic/exocytotic transport pathway. As a result of this, it is able to hone to tumor cells and make them permeable to transport of many types of cancer therapies. This makes traditional cancer therapies better and less toxic. One study showed that Doxorubicin, liposomal Doxorubicin, Herceptin or Abraxane had greater drug accumulation in the tumor by up to 40-fold than mice injected with one of the drugs alone. The drug-peptide combination was as effective as threefold higher doses of chemotherapeutic drugs alone.

PNC-27

This peptide has been found to be cytotoxic to human cancer cells while having no effect on healthy cells and is functional almost across all cancer cell types. This peptide is a membrane active anticancer peptide that has been found to kill cancer cells by inducing membrane lysis via cellular necrosis. It has been designed to bind tightly to the p53-binding pocket on the mdm2 protein, a negative regulator of the P53 tumor suppressor. P53 is usually not expressed in high degrees in normal cells while almost all cancers have a mechanism to decrease the functionality of P53, which can stop cellular replication. Thus, cancer cells can be selectively targeted for necrosis and death. Since the mechanism of tumor lysis is so intensive, careful attention is required for dosage and frequency, and therefore requires in-office administration, and regular lab draws.

PT-141

Bremelanotide (PT-141) was developed from the peptide hormone Melanotan II. In initial testing, Melanotan II induced darkening of skin pigment, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction, it is an effective medication in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.

It is estimated that 43% of women (30 million is the US) suffer from sexual dysfunction and 30 million men suffer from ED, with incidence increasing 2-3-fold between ages 40-70. Bremelanotide currently has no contraindications and is 80% effective in people who don’t respond to Viagra or Cialis.

Tesamorelin

Tesamorelin is a growth hormone releasing hormone analog that increases IGF-1 levels in men and women, by an average of 181 micrograms/liters. It binds to and stimulates GHRH receptors with similar potency as endogenous GHRH. It has a host of other benefits including nootropic effects and reducing triglycerides.

Tesamorelin has subsequently been shown to decrease carotid intima-media thickness (cIMT), visceral adipose tissue (VAT), and c-reactive protein (CRP). It has not been linked to significantly affect other pituitary hormones and their respective mechanisms in the body. Additionally, it can improve cognitive
function for healthy seniors and patients with an increased risk of Alzheimer’s disease, due to mild cognitive impairment.

Thymosin

Thymosin α-1 is (TA-1) responsible for restoring immune function, particularly cell mediated immune function. Recent studies showed that the TA-1 molecule increased major histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role. The drug is in Phase III trials for the treatment of hepatitis C and in Phase II trials for hepatitis B. Physicians are also using thymosin for chronic fatigue, and Lyme disease, cancer, viral diseases and an anti-aging peptide as well. TA 1 is thought to modulate the immune system by augmenting T-cell function. TA1 may affect thymocytes by stimulating their differentiation or by converting them to active T cells. TA1 is rapidly absorbed, achieving peak serum concentrations within two hours. Blood levels return to baseline within 24 hours, and the serum half-life is approximately 2 hours.

VIP

Vasoactive intestinal polypeptide (VIP) is a naturally produced neuropeptide that functions as a neuromodulator and neurotransmitter. It is a potent vasodilator, regulates smooth muscle activity, epithelial cell secretion, and blood flow in the gastrointestinal tract. As a chemical messenger, it functions as a neurohormone and paracrine mediator. Therapeutically, it is often dosed nasally in patients with mold toxicity and other biotoxin illnesses. In these patients, exogenous administration can help support healthy hormone levels, works to limit inflammation, regulates the immune system, and help in the healing activity of the brain.