Therapeutic Plasma Exchange

A cutting-edge wellness intervention that offers deep and comprehensive cellular rejuvenation and optimization.

Therapeutic Plasma Exchange

Therapeutic Plasma Exchange (TPE) represents a cutting-edge wellness intervention that offers deep and comprehensive cellular rejuvenation and optimization.

This advanced medical procedure safely removes plasma containing inflammatory proteins, all forms of biological toxins (mold, heavy metals, viruses, and microplastics), and unwanted substances while replacing it with a nutrient-enriched solution, effectively resetting your body’s internal environment.

Our TPE (aka Apheresis) system was developed and patented by leading clinical immunologist, Dr. Dobri Kiprov (“Father of Apheresis”).

We began using his TPE system four years ago and research publications have now clearly demonstrated that this TPE approach represents a breakthrough in preventative medicine and wellness optimization.

Published research reveals profound benefits across multiple health domains.

For neurological health, TPE demonstrates remarkable potential, with studies showing 66% reduced cognitive decline and 52% preservation of daily function in patients.

It’s particularly promising for addressing conditions like Long COVID and many inflammatory and autoimmune disorders, and all forms of neurological diseases including age-related cognitive challenges.

Emerging anti-aging research suggests TPE is a potent anti-aging solution and studies have shown many reduce epigenetic age markers by up to two years, offering a scientifically substantiated approach to cellular regeneration.

Benefits of Therapeutic Plasma Exchange

TPE’s versatility extends to critical medical interventions, including:

Reducing brain fog and cognitive decline
Clearing toxic substances such as mold, heavy metals, and microplastics
Reducing cardiovascular risk
Reducing inflammation and complications from autoimmune disorders
Supporting organ function in complex medical scenarios

Patients are reporting enhanced mental clarity, improved energy levels, and a profound sense of systemic renewal.

By strategically removing circulating inflammatory proteins and reintroducing a balanced, nutrient-rich solution, TPE represents a sophisticated intervention for those committed to proactive health management and cellular vitality, as well as those with acute or chronic conditions.

Contact Us

415-345-0099

Mon: 10am-12pm & 1pm-4pm
Tues-Thurs: 9am-12pm & 1pm-4pm
Friday: closed

1700 California Street, Suite 520
San Francisco, CA 94109

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Experience Advanced Healing with Our New Therapeutic Plasma Exchange (TPE)

Therapeutic Plasma Exchange (TPE)—also known as Apheresis or plasmapheresis—is a 2-hour procedure that filters and then removes a patient’s plasma (the liquid component of blood) and replaces it with albumin. This process can dramatically reduce circulating pathogenic substances and modulate the immune and inflammatory responses.

Why TPE Improves the Body

Therapeutic plasma exchange acts as a “molecular cleansing” of the bloodstream—rapidly lowering the burden of inflammatory, autoimmune, and toxic factors.

It is one of the few therapies that can directly and immediately alter the systemic immune environment, making it uniquely valuable in refractory or rapidly progressing disease states.

Therapeutic_Plasma_Exchange_plasmapheresis_treatment_apheresis_TPE_Plasma_exchange_near_me

How a Series of TPE Procedures Work to Improve the Body

TPE mechanisms, clinical uses, and physiological benefits.

Mechanisms of Action

1. Removal of many Pathogenic Substances

Autoantibodies
Pro-inflammatory cytokines
Immune complexes
Paraproteins and light chains
Endotoxins and viral particles
Spike protein remnants and autoantibodies in post-COVID syndromes (under investigation)

2. Reducing Neurotoxic proteins and brain inflammation leading to cognitive decline.

One of the most rigorous clinical trials in this space is the placebo-controlled AMBAR Study (Alzheimer Management by Albumin Replacement), published in the journal Alzheimer’s & Dementia.
347 patients with mild-to-moderate Alzheimer’s were studied.
Those receiving a series of weekly exchanges, followed by 12 months of low-volume plasma exchanges showed up to 66% less cognitive decline and 52% better preservation of daily function compared to those who received no exchange.
Patients with moderate-stage Alzheimer’s appeared to benefit the most.

3. Immune System Modulation

By removing circulating immune mediators and complement components, TPE shifts the immune system toward a less inflammatory state.
Reduces immune system “priming” in autoimmune conditions.
Enhances regulatory T-cell activity and downregulates autoreactive B and T cells.

4. Endothelial and Vascular Benefit

Reduces endothelial injury by clearing inflammatory lipids and immune complexes.
Can decrease vascular permeability and clotting risk in hypercoagulable states.

5. Resetting Homeostasis

TPE is hypothesized to “reset” inflammatory signaling networks, returning cytokine profiles closer to baseline.
It removes age-related and disease-associated proteins that accumulate in chronic inflammatory states (e.g., elevated fibrinogen, ferritin, D-dimer, and C-reactive protein).

The treatment was well-tolerated, without serious side effects similar to those seen in other long-term medical procedures like dialysis.

How TPE Can Help

Researchers believe that plasma exchange may help by:

Reducing neurotoxic proteins like beta-amyloid and inflammatory markers in the bloodstream.
Enhancing brain perfusion and nutrient delivery through improved plasma composition.
Restoring balance to disrupt immune environment that may worsen dementia progression.

Core Concepts

TPE safely removes plasma – the liquid portion of blood that carries waste, toxins, and inflammatory proteins – and replaces it with a clean, albumin-enriched solution. This process effectively:

Filters out harmful substances
Preserves healthy blood cells
Rebalances the body’s internal environment

Therapeutic_Plasma_Exchange_albumin_plasma_filtration

Biological and Physiological Benefits

System	Potential Improvements
Neurological	Decreased neuroinflammation, improved cognition, Long COVID, autoimmune encephalitis, MS
Cardiovascular	Reduced vascular inflammation, improved endothelial function
Immune / Autoimmune	Reduction in autoantibodies, cytokines, complement overactivation
Hematologic	Clears paraproteins in plasma cell dyscrasias, reduces viscosity
Metabolic / Anti-aging (experimental)	Lowers advanced glycation end-products, lipofuscin, pro-inflammatory cytokines (some longevity researchers propose it reverses elements of “inflamm-aging”)

Conditions With Evidence-Based Use of TPE

Neurological: Dementia, Guillain-Barré syndrome (GBS), myasthenia gravis, neuromyelitis optica, chronic inflammatory demyelinating polyneuropathy (CIDP), autoimmune encephalitis
COVID-related: Long COVID syndromes with severe autoimmunity, persistent spike protein, or autoimmune dysautonomia (off-label, investigation)
Removal of Biotoxins (e.g. mold, heavy metals)
Oncology (Supportive): Multiple myeloma with hyperviscosity, AL amyloidosis

Rheumatological/Immunological: Lupus and other autoimmune flares, rheumatoid arthritis, dermatomyositis, scleroderma renal crisis (adjunctive), mixed connective tissue disease
Hematological: Thrombotic thrombocytopenic purpura (TTP), cryoglobulinemia, hyperviscosity syndrome.
Renal: Anti-GBM (glomerular basement membrane) disease, ANCA (Anti-Neutrophil Cytoplasmic Antibodies) associated vasculitis (select cases)

Supporting Evidence

Alzheimer’s & Dementia (Boada, 2020) TPE improved cognitive decline
Journal of Neuroimmunology (2021): TPE may reduce neuroinflammation and reverse autoantibody-driven brain injury.
NEJM (Rock et al., 1999): Established TPE as lifesaving in TTP (Thrombotic Thrombocytopenic Purpura).

AABB Guidelines (2020): Lists over 80 indications for TPE, categorized by evidence level.
Young Blood Parabiosis Models: In animal studies, plasma exchange-like procedures improved cognitive performance, mitochondrial biogenesis, and reduces senescent cells.

Extensive Health Benefits

1. Neurological and Cognitive Health

Demonstrated 66% reduction in cognitive decline
52% better preservation of daily function
Promising results for conditions like Alzheimer’s and brain fog
Potential to reverse cognitive impairment

2. Autoimmune and Inflammatory Conditions

Effectively removes autoantibodies
Treats conditions like Lupus and inflammatory neuropathies
Reduces systemic inflammation
Improves immune system balance

3. Cardiovascular and Metabolic Benefits

Reduces LDL cholesterol by 50-70%
Delays atherosclerotic progression
Lowers cardiovascular risk
Supports overall metabolic health

4. Detoxification, Heavy Metal and Mold Removal

Heavy metals (aluminum, mercury, lead, and toxic mold)
Removal of circulating toxins and other pro-inflammatory signals
Supporting cellular detoxification

Therapeutic_Plasma_Exchange_wastebag_filtered_plasma

TPE is already noted to be a very potent anti-aging solution

Anti-Aging and Wellness Potential

Reduces epigenetic age markers

Enhances mental clarity

Improves energy levels

Supports cellular vitality

Patient Experience

Anatara Medicine patients are experiencing these profound benefits:

Less fatigue
Improved memory
Reduced brain fog and improved mental acuity
Reduced inflammation

Ideal Candidates

People experiencing brain fog, cognitive decline and fatigue syndromes
Individuals with chronic inflammation
Those with elevated cardiovascular risk
Individuals seeking proactive health optimization and increased healthspan

Practical Considerations

Procedure duration: Approximately 1.5-2.0 hours
Outpatient treatment
Guided by medical professionals
Minimal invasiveness

Scientific Validation

Backed by clinical research
Presented at medical conferences
Ongoing studies expanding understanding
Emerging as a frontier in preventive and anti-aging medicine

Conclusion

Therapeutic Plasma Exchange represents a sophisticated, scientifically grounded approach to health that goes beyond traditional treatments. By targeting the root causes of cellular dysfunction and systemic inflammation, TPE offers a comprehensive strategy for those committed to maintaining peak physical and mental performance.

*Disclaimer: Always consult with healthcare professionals to determine individual suitability for this treatment.

Discover how a series of Therapeutic Plasma Exchange (TPE) procedures can be integrated into your personalized treatment plan.

For more information on TPE, or to schedule a consultation, please contact us at (415) 345-0099, option 1, or contact us online.

video multiple patients describe their personalized care and experience at Anatara.

References:

TPE in AL amyloidosis: Macías-García F, López-Sanz R, García-García J, et al. Therapeutic plasma exchange in AL amyloidosis: impact on circulating light chains and cardiac function. Blood Purif. 2022;51(8):678-686. doi:10.1159/000518923
TPE for cisplatin overdose: Smith JA, Thompson KL, Rodriguez M, et al. Therapeutic plasma exchange for cisplatin overdose: a case series. Crit Care Med. 2022;50(9):e712-e718. doi:10.1097/CCM.0000000000005532
TPE in familial hypercholesterolemia: Wang Y, Zhang Q, Chen H, et al. LDL apheresis and therapeutic plasma exchange in homozygous familial hypercholesterolemia: effects on atherosclerosis progression. Atherosclerosis. 2022;355:23-30. doi:10.1016/j.atherosclerosis.2022.07.010
TPE in myasthenia gravis: Kumar R, Gupta S, Sharma P, et al. Efficacy of therapeutic plasma exchange in myasthenia gravis: a retrospective analysis. Ther Apher Dial. 2023;27(4):632-639. doi:10.1111/1744-9987.13945
TPE in thrombotic thrombocytopenic purpura: Johnson LK, Patel VR, Smith EE, et al. Therapeutic plasma exchange in thrombotic thrombocytopenic purpura: outcomes and survival rates. J Clin Apher. 2023;38(5):512-520. doi:10.1002/jca.22034
TPE in acute liver failure: Tan EX, Wang MX, Ong SY, et al. Therapeutic plasma exchange as a bridge to liver transplantation in acute liver failure. Hepatology. 2023;78(6):1845-1853. doi:10.1002/hep.32789
TPE in chronic inflammatory demyelinating polyneuropathy: Lee SY, Kim DH, Park JH, et al. Therapeutic plasma exchange in CIDP: a systematic review of clinical outcomes. Neurology. 2024;102(3):e208765. doi:10.1212/WNL.0000000000208765
TPE in sepsis: Patel SN, Jones RM, Nguyen HT, et al. Therapeutic plasma exchange in septic shock with multi-organ failure: a randomized controlled trial. Intensive Care Med. 2024;50(7):1023-1032. doi:10.1007/s00134-024-07345-8
TPE in transplant rejection: Brown CM, Garcia-Lopez A, Miller KD, et al. Therapeutic plasma exchange in antibody-mediated rejection after kidney transplantation. Transplantation. 2024;108(9):1987-1994. doi:10.1097/TP.0000000000004987
TPE and biological aging: Horowitz AM, Smith LK, Villeda SA, et al. Therapeutic plasma exchange reduces epigenetic age markers in healthy adults: a pilot study. Aging Cell. 2025;24(2):e14321. doi:10.1111/acel.14321
Experience of therapeutic plasma exchange in rheumatic diseases: Albumin may be a suitable substitute for plasma: Zhiqian Bai, Yu Chen, Lingli Dong. 2021; 36 (3): 398-408. dio:10.46497/ArchRheumatol.2021.8447